Study of bactericidal properties of carbohydrate-stabilized platinum oxide nanoparticles
1 Department of Biology, Basic Science Institute, University Street, Payam-e-Noor University, Yazd, 89418-57417, Iran
2 Department of Chemical Injury Research Center, Medical Science Institute, Sheikh Bahaei Street, Baqiyatallah Medical Science University, Tehran, 14359-44711, Iran
3 Department of Biology, Basic Science Institute, Shahid Babaei Street, Imam Houssein University, Tehran, 479231-98662, Iran
4 Department of Applied Biotechnology and Environmental Research Center, Sheikh Bahaei Street, Baqiyatallah Medical Science University, Tehran, 14359-44711, Iran
5 Department of Biology, Basic Science Institute, Nakhl Street, Payam-e-Noor University, Tehran, 19395-4697, Iran
International Nano Letters 2012, 2:21 doi:10.1186/2228-5326-2-21Published: 24 September 2012
Platinum oxide nanoparticles were prepared by a simple hydrothermal route and chemical reduction using carbohydrates (fructose and sucrose) as the reducing and stabilizing agents. In comparison with other metals, platinum oxide has less environmental pollution. Therefore, Pt is considered an appropriate candidate to deal with environmental pathogens. The crystallite size of these nanoparticles was evaluated from X-ray diffraction, atomic force microscopy, and transmission electron microscopy (TEM) and was found to be 10 nm, which is the demonstration of EM bright field and transmission electron microscopy. The effect of carbohydrates on the morphology of the nanoparticles was studied using TEM. The nanoparticles were administered to the Pseudomonas stutzeri and Lactobacillus cultures, and the incubation was done at 37°C for 24 h. The nanocomposites exhibited interesting inhibitory as well as bactericidal activity against P. stutzeri and Lactobacillus species. Incorporation of nanoparticles also increased the thermal stability of the carbohydrates. The results of this paper showed that carbohydrates can serve as a carrier for platinum oxide nanoparticles, and nanocomposites can have potential biological applications.